A really great 5E sci-fi system. As somebody who's looked into almost every SF RPG system out there, this one strikes the best balance for me.
When I break down sci-fi RPGs, I think in terms of two key metrics: 1) How much do I like the ruleset? 2) How heavy does that ruleset weigh on the setting/creativity of the DM?
A common problem I found when I was trying to find a system I liked, was that advantages in one of these categories was always equally outweighed by negatives in the other category.
Hyperlanes for 5E uses the 5th Edition DnD ruleset, which for me and my group strike the right balance between tactical play and cinematic, rules-light play; however, Hyperlanes also creates an overly hard SF setting for what I'd like to play. To add some of the more fantastical elements I look for in an RPG, I'd find myself needing to homebrew entire classes and "spell" lists.
Stars Without Number (Revised Edition or Original, or even Traveler) has a better balance when it comes to giving the player control over how fantastical vs hard their setting feels, but the rulesets are too roguelike for my liking.
Starfinder, while offering some interesting rules dives too deeply into the 3rd-4th edition "Pit of Math" that characterizes the Pathfinder games and the rules provided force the idea of magic a bit too deeply into the settting (i.e. the word magic and spell will come up frequently and explicitly and there are literal dragons). This can be almost as much work to expunge as it is to create new classes from scratch.
If you're like me and have wanted a reasonable, middle-of-the-line science fiction setting that is neither strictly hard nor strictly fantastical (think Mass Effect) for using the 5th edition ruleset, this is exactly it.
While I might have done some things differently in terms of language usage to make it slightly more generic (i.e. Sorium, Esper, etc), I don't mind the basic language the game provides to you and I found once I had engaged with it for a bit in actual play, I was able to avoid having these setting elements feel at the forefront of the story.
Overall, it's a definite recommend for me, if only because I LOVE LOVE LOVE RPG books and this one is quite beautiful and nicely laid out. We've bought everything in PDF/book format so far that is available. My only regret is that there is not really any kind of convenient digital tool for esper power look-up/character creation available. I'd love to see a standalone app, an import file for 5th Edition Spellbook, etc. anything really. I had considered making an import file myself, but I haven't had the chance to look at what is OGL/OGC in Esper Genesis and what is not.