Esper Genesis - A Science Fantasy/Fiction game based on the 5th ed D&D rules.
You get all new races and classes, though it's not too hard to see how some of them were derived from the originals to fit this setting.
A setting where discovery of the Cauldrons, mysterious planetoid/planetary scale artifacts from an unknown source, have spawned new technologies and new powers, Esper Genesis.
Ok, it's a star spanning sci-fi romp with it's own fantasy components. Psionics and Esper powers are definitley a fantasy component that is very common in scifi. The game lends itself very well to a nice range of settings that could easily include Star Wars, Mass Effect, or even the Retief series of books if you are so inclined, though it does have it's own setting included.
I've found the writing clear and easy to understand, and the artwork astounding! In my opinion, I've rarely seen artwork of this caliber in sci-fi games, or even games in general.
It even has a good spaceship combat system that gives people things to do other than wait for the pilot or gunner to win or get everyone spaced.
If you're curious, why not take a look at the Basic Rules, that file is free. Esper Genesis Basic Rules
I own or have otherwise looked at a variety of scifi rpg rulesets for star romping, and this is one is my favorite.